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KMID : 0362919900080020151
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1990 Volume.8 No. 2 p.151 ~ p.154
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Acute Response to Co-60 Total Body Irradiation (TBI) With 600 cGy at 3 Different Does Rates in the Mice
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Kang Cheol-Hoon
Kim Sung-Kyu
Shin Sei-One
Kim Myung-Se
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Abstract
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The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cGy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cGy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cGy/minute may be applicable for clinical therapy with careful evaluation of patient’s condition.
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KEYWORD
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Total body irradiation, Dose rate, Acute effects
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